Retinoic acid receptor antagonists for male contraception: current status†

Current status of acid pump antagonists (reversible PPIs).

The introduction of H2-receptor antagonists in the mid-1970s provided, for the first time, acceptable medical therapy for acid-related diseases. Their short duration of action and single receptor targeting, however, limited satisfactory treatment of patients. Today the control of gastric acid secretion can be effectively achieved by direct inhibition of the H+, K(+)-ATPase. Inhibition of the pr...

H2 Receptor Antagonists

This article has no abstract

Retinoic Acid Receptor-Mediated Induction

Regulation of Retinoic Acid Receptor

The peroxisome proliferator-activated receptor (PPAR ) is a nuclear receptor family member that can form a heterodimeric complex with retinoid X receptor (RXR) and initiate transcription of target genes. In this study, we have examined the effects of the PPAR ligand ciglitazone and the RXR ligand SR11237 on growth and induction of retinoic acid receptor (RAR) expression in breast and lung cance...

Receptor-selective Retinoids Implicate Retinoic Acid Receptor

The effect of retinoids on malignant cells and embryos indicates that retinoids influence the expression of growth factors or alter the response of cells to growth factors. The bone morphogenetic proteins, Bmp-2 and Bmp-4, are candidates for such growth factors because retinoic acid (RA) treatment of F9 embryonal carcinoma cells induced Bmp-2 mRNA, while simultaneously repressing Bmp-4 levels. ...